NS-032 is a potent inhibitor of cyclin-dependent kinases

NS-032 is a potent inhibitor of cyclin-dependent kinases

SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).

QQ图片20150721095014

Abbreviations: AUCINF, area under the concentration versus time curve from time zero to infinity; CL, total body clearance; Cmax, maximum plasma concentration; T1/2, terminal half-life; MRTINF, mean residency time when the drug concentration-time profile is extrapolated to infinity; Vss, apparent volume of distribution at steady-state; CV%, percent coefficient of variation. * n = 6.