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Wales from 1988 to 1999. Vet Rec 150: 649654. 27. Aziz RK, Bartels D, Ideal AA, DeJongh M, Disz T, et al. The RAST Server: rapid annotations employing subsystems technology. BMC Genomics 9: 75. 28. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ Fundamental BI-78D3 biological activity regional alignment search tool. J Mol Biol 215: 403410. 29. Ellis RJ, Bruce KD, Jenkins C, Stothard JR, Ajarova L, et al. Comparison in the distal gut microbiota from men and women and animals in Africa. PLoS A single eight: e54783. 30. Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, et al. QIIME permits evaluation of high-throughput neighborhood sequencing information. Nat Solutions 7: 335336. 31. Edgar RC Search and clustering orders of magnitude more rapidly than BLAST. Bioinformatics 26: 24602461. 32. Haas BJ, Gevers D, Earl AM, Feldgarden M, Ward DV, et al. Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons. Genome Res 21: 494504. 33. Wang Q, Garrity GM, Tiedje JM, Cole JR Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol 73: 52615267. 34. DeSantis TZ, Hugenholtz P, Larsen N, Rojas M, Brodie EL, et al. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol 72: 50695072. 35. Kaczmarek FS, Gootz TD, Dib-Hajj F, Shang W, Hallowell S, et al. Genetic and molecular characterization of beta-lactamase-negative ampicillinresistant Haemophilus LED 209 biological activity influenzae with unusually higher resistance to ampicillin. Antimicrob Agents Chemother 48: 16301639. 36. Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, et al. The TetR household of transcriptional repressors. Microbiol Mol Biol Rev 69: 326356. 37. Dean CR, Narayan S, Daigle DM, Dzink-Fox JL, Puyang X, et al. Part of the AcrAB-TolC efflux pump in figuring out susceptibility of Haemophilus influenzae towards the novel peptide deformylase inhibitor LBM415. Antimicrob Agents Chemother 49: 31293135. 38. Skold O Resistance to trimethoprim and sulfonamides. Vet Res 32: 261 273. 39. Fiebelkorn KR, Crawford SA, Jorgensen JH Mutations in folP associated with elevated sulfonamide MICs for Neisseria meningitidis clinical isolates from five continents. Antimicrob Agents Chemother 49: 536540. 40. Swedberg G, Ringertz S, Skold O Sulfonamide resistance in Streptococcus pyogenes is connected with variations in the amino acid sequence of its chromosomal dihydropteroate synthase. Antimicrob Agents Chemother 42: 10621067. 41. Haasum Y, Strom K, Wehelie R, Luna V, Roberts MC, et al. Amino acid repetitions within the dihydropteroate synthase of Streptococcus pneumoniae lead to sulfonamide resistance with restricted effects on substrate K. Antimicrob Agents Chemother 45: 805809. 42. Jakobsson HE, Jernberg C, Andersson AF, Sjolund-Karlsson M, Jansson JK, et al. Short-term antibiotic therapy has differing long-term impacts around the human throat and gut microbiome. PLoS A single five: e9836. 43. Arthur M, Andremont A, Courvalin P Distribution of erythromycin esterase and rRNA methylase genes in members in the loved ones Enterobacteriaceae very resistant to erythromycin. Antimicrob Agents Chemother 31: 404 409. 44. Aminov RI The role of antibiotics and antibiotic resistance in nature. Environ Microbiol 11: 29702988. 45. van Hoek AH, Mevius D, Guerra B, Mullany P, Roberts AP, et al. Acquired antibiotic resistance genes: an overview. Front Microbiol two: 203. 46. Danner DB, Smith HO, Narang SA Building of DNA recognition web-sites active in Haemo.Wales from 1988 to 1999. Vet Rec 150: 649654. 27. Aziz RK, Bartels D, Greatest AA, DeJongh M, Disz T, et al. The RAST Server: speedy annotations working with subsystems technology. BMC Genomics 9: 75. 28. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ Basic nearby alignment search tool. J Mol Biol 215: 403410. 29. Ellis RJ, Bruce KD, Jenkins C, Stothard JR, Ajarova L, et al. Comparison of your distal gut microbiota from men and women and animals in Africa. PLoS One 8: e54783. 30. Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, et al. QIIME allows analysis of high-throughput community sequencing information. Nat Strategies 7: 335336. 31. Edgar RC Search and clustering orders of magnitude faster than BLAST. Bioinformatics 26: 24602461. 32. Haas BJ, Gevers D, Earl AM, Feldgarden M, Ward DV, et al. Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons. Genome Res 21: 494504. 33. Wang Q, Garrity GM, Tiedje JM, Cole JR Naive Bayesian classifier for speedy assignment of rRNA sequences in to the new bacterial taxonomy. Appl Environ Microbiol 73: 52615267. 34. DeSantis TZ, Hugenholtz P, Larsen N, Rojas M, Brodie EL, et al. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol 72: 50695072. 35. Kaczmarek FS, Gootz TD, Dib-Hajj F, Shang W, Hallowell S, et al. Genetic and molecular characterization of beta-lactamase-negative ampicillinresistant Haemophilus influenzae with unusually higher resistance to ampicillin. Antimicrob Agents Chemother 48: 16301639. 36. Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, et al. The TetR family of transcriptional repressors. Microbiol Mol Biol Rev 69: 326356. 37. Dean CR, Narayan S, Daigle DM, Dzink-Fox JL, Puyang X, et al. Part on the AcrAB-TolC efflux pump in figuring out susceptibility of Haemophilus influenzae towards the novel peptide deformylase inhibitor LBM415. Antimicrob Agents Chemother 49: 31293135. 38. Skold O Resistance to trimethoprim and sulfonamides. Vet Res 32: 261 273. 39. Fiebelkorn KR, Crawford SA, Jorgensen JH Mutations in folP linked with elevated sulfonamide MICs for Neisseria meningitidis clinical isolates from 5 continents. Antimicrob Agents Chemother 49: 536540. 40. Swedberg G, Ringertz S, Skold O Sulfonamide resistance in Streptococcus pyogenes is linked with variations in the amino acid sequence of its chromosomal dihydropteroate synthase. Antimicrob Agents Chemother 42: 10621067. 41. Haasum Y, Strom K, Wehelie R, Luna V, Roberts MC, et al. Amino acid repetitions inside the dihydropteroate synthase of Streptococcus pneumoniae result in sulfonamide resistance with restricted effects on substrate K. Antimicrob Agents Chemother 45: 805809. 42. Jakobsson HE, Jernberg C, Andersson AF, Sjolund-Karlsson M, Jansson JK, et al. Short-term antibiotic therapy has differing long-term impacts on the human throat and gut microbiome. PLoS One five: e9836. 43. Arthur M, Andremont A, Courvalin P Distribution of erythromycin esterase and rRNA methylase genes in members from the family Enterobacteriaceae hugely resistant to erythromycin. Antimicrob Agents Chemother 31: 404 409. 44. Aminov RI The role of antibiotics and antibiotic resistance in nature. Environ Microbiol 11: 29702988. 45. van Hoek AH, Mevius D, Guerra B, Mullany P, Roberts AP, et al. Acquired antibiotic resistance genes: an overview. Front Microbiol 2: 203. 46. Danner DB, Smith HO, Narang SA Construction of DNA recognition sites active in Haemo.

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