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E prognosis in Chinese gastric cancer. Int J Clin Exp Pathol.
E prognosis in Chinese gastric cancer. Int J Clin Exp Pathol. 2015;8(8):9264?1. 61. He X, Lin X, Cai M, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28154141 Zheng X, Lian L, Fan D, Wu X, Lan P, Wang J. Overexpression of order Peficitinib hexokinase 1 as a poor prognosticator in human colorectal cancer. Tumour Biol. 2016;37(3):3887?5. 62. Hooft L, van der Veldt AA, van Diest PJ, Hoekstra OS, Berkhof J, Teule GJ. Molthoff CF: [18 F]fluorodeoxyglucose uptake in recurrent thyroid cancer is related to hexokinase i expression in the primary tumor. J Clin Endocrinol Metab. 2005;90(1):328?4.Submit your next manuscript to BioMed Central and we will help you at every step:?We accept pre-submission inquiries ?Our selector tool helps you to find the most relevant journal ?We provide round the clock customer support ?Convenient online submission ?Thorough peer review ?Inclusion in PubMed and all major indexing services ?Maximum visibility for your research Submit your manuscript at www.biomedcentral.com/submit
Siddaramappa et al. BMC Genomics 2011, 12:570 http://www.biomedcentral.com/1471-2164/12/RESEARCH ARTICLEOpen AccessHorizontal gene transfer in Histophilus somni and its role in the evolution of pathogenic strain 2336, as determined by comparative genomic analysesShivakumara Siddaramappa1,2, Jean F Challacombe2, Alison J Duncan1, Allison F Gillaspy3, Matthew Carson3, Jenny Gipson3, Joshua Orvis3, Jeremy Zaitshik3, Gentry Barnes3, David Bruce2, Olga Chertkov2, J Chris Detter2, Cliff S Han2, Roxanne Tapia2, Linda S Thompson2, David W Dyer3 and Thomas J Inzana1*AbstractBackground: Pneumonia and myocarditis are the most commonly reported diseases due to Histophilus somni, an opportunistic pathogen of the reproductive and respiratory tracts of cattle. Thus far only a few genes involved in metabolic and virulence functions have been identified and characterized in H. somni using traditional methods. Analyses of the genome sequences of several Pasteurellaceae species have provided insights into their biology and evolution. In view of the economic and ecological importance of H. somni, the genome sequence of pneumonia strain 2336 has been determined and compared to that of commensal strain 129Pt and other members of the Pasteurellaceae. Results: The chromosome of strain 2336 (2,263,857 bp) contained 1,980 protein coding genes, whereas the chromosome of strain 129Pt (2,007,700 bp) contained only 1,792 protein coding genes. Although the chromosomes of the two strains differ in size, their average GC content, gene density (total number of genes predicted on the chromosome), and percentage of sequence (number of genes) that encodes proteins were similar. The chromosomes of these strains also contained a number of discrete prophage regions and genomic islands. One of the genomic islands in strain 2336 contained genes putatively involved in copper, zinc, and tetracycline resistance. Using the genome sequence data and comparative analyses with other members of the Pasteurellaceae, several H. somni genes that may encode proteins involved in virulence (e.g., filamentous haemaggutinins, adhesins, and polysaccharide biosynthesis/modification enzymes) were identified. The two strains contained a total of 17 ORFs that encode putative glycosyltransferases and some of these ORFs had characteristic simple sequence repeats within them. Most of the genes/loci common to both the strains were located in different regions of the two chromosomes and occurred in opposite orientations, indicating genome rearrangement since their divergence from a.

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