Daily Archives: February 14, 2017

We believe such S1P synthesis may contribute to PMN activation and subsequent increases in endothelial permeability, but further investigations will be needed to test this hypothesis

Since PMN Ca2+ inflow relies upon on S1P synthesis by Sphk1 [16], we following examined no matter whether exposure to mtDNA increased PMN Sphk1 expression. As revealed in Figure 7B, Sphk1 expression in PMN (at minimum at the mRNA stage) was increased by mtDNA, suggesting that mtDNA activates PMN by increasing Sphk1 and S1P, therefore…

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