Ariables using a propensity score analysis; (III) and finally, competing risks were taken into account in all analysis. In conclusion, hypokalemia was significantly associated with higher risk of cardiovascular, infectious and all-cause mortality, even after adjustments for competing risks and with wellbalanced groups. The underlying mechanisms behind the association of hypokalemia and infectious mortality deserve further investigation. Finally, our results raise the need for future intervention studies looking at the effect of hypokalemia bmjopen-2015-010112 Actidione price correction on patient survival.Supporting InformationS1 Table. Potassium variability–Overall population. (DOCX) S2 Table. Potassium variability–Matched patients. (DOCX)PLOS ONE | DOI:10.1371/journal.pone.0127453 June 19,10 /Hypokalemia and Outcomes in Peritoneal DialysisS3 Table. Risk factors for overall mortality. (DOCX) S4 Table. Risk factors for cardiovascular mortality. (DOCX) S5 Table. dar.12119 Risk factors for cardiovascular mortality in the matched cohort. (DOCX) S6 Table. Risk factors for infectious mortality. (DOCX) S7 Table. Independent risk factors for infectious mortality in the matched cohort. (DOCX) S8 Table. Time to first peritonitis episode–Overall population. (DOCX) S9 Table. Time to first peritonitis episode–Matched patients. (DOCX) S1 File. Ethic Review Boards that approved the study. (DOCX)AcknowledgmentsThe following centers participated in BRAZPD and contributed to the preparation of this article: Ameneg, Associa o Hosp. Bauru, Biocor Hosp. Doencas Cardiologicas, Casa de Saude e Mat N. Sra. Perp. Socorro, CDR Curitiba, CDR Goiania, CDR Imperatriz, CDR Sao Jose Pinhais, CDTR_Centro Dialise Transplante Renal, Centro Nefrologia Teresopolis, Centro Nefrologico Minas Gerais, Centro Trat. Doencas AZD-8835 msds Renais Joinville, Centro Tratamento Renal Zona Sul, CLINEF Rio De Janeiro, CLINEPA Clinica de Nefrologia da Paraiba, CLINES, Clinese, Clinica do Rim do Carpina, Clinica Evangelico S/C Ltda, Clinica Nefrologia de Franca, Clinica de Nefrologia Santa Rita, Clinica de Nefrologica Sao Goncalo, Clinica Paulista de Nefrologia, Clinica Renal Manaus, Clinica Senhor Do Bonfim, Clinica Senhor Do Bonfim Ltda Filial, Clinica Tratamento Renal, Cuiaba Cenec, Clire Clinica de Doencas Renais, Famesp Botucatu, Unicamp_Univ. Est Campinas, Hosp. Clinicas FMRPUSP, Funda o Civil Casa Mis Franca, Funda o Inst Mineiro Est Pesq Nefrol, Gamen Rio de Janeiro, Gdf Hospital de Base, Histocom Sociedade Civil Ltda, Hosp Univ Prof Edgard Santos, Hosp Benef. Portuguesa Pernambuco, Hospital Cidade Passo Fundo, Hospital Clinica Univ Fed Goias, Hospital E Maternidade Angelina Caron, Hospital Evangelico Vila Velha Es, Hospital Geral Bonsucesso, Hospital Geral de Goiania, Hospital Infantil Joana de Gusmao, Hospital S Joao Deus, Hospital S Jorge, Hospital S Jose do Avai, Hosp Sao Vicente de Paula_J Pessoa, Hosp Sao Vicente de Paulo, Hospital Servidor do Estado Ipase, Hospital Univ Presidente Dutra Ma, Hospital Universitario Antonio Pedro, Hospital Vita Volta Redonda S/A, Iamspe Sao Paulo, Imip, Inst Capixaba Doencas Renais, Inst Capixaba Doencas Renais Cariacica, Inst Capixaba Doencas Renais Serra, Inst do Rim de Fortaleza, Inst do Rim de Marilia, Inst do Rim do Parana S/C Ltda, Inst do Rim Santo Antonio da Platina, Inst Hemodialise de Sorocaba, Inst Medicina Nuclear Endocrina, Inst Nefrologia de Mogi Das Cruzes, Inst Nefrologia de Suzano, Inst Nefrologia Souza e Costa, Inst Urologia e Nefrol Barra Mansa, Inst Urologia e Nefrol Sj Ri.Ariables using a propensity score analysis; (III) and finally, competing risks were taken into account in all analysis. In conclusion, hypokalemia was significantly associated with higher risk of cardiovascular, infectious and all-cause mortality, even after adjustments for competing risks and with wellbalanced groups. The underlying mechanisms behind the association of hypokalemia and infectious mortality deserve further investigation. Finally, our results raise the need for future intervention studies looking at the effect of hypokalemia bmjopen-2015-010112 correction on patient survival.Supporting InformationS1 Table. Potassium variability–Overall population. (DOCX) S2 Table. Potassium variability–Matched patients. (DOCX)PLOS ONE | DOI:10.1371/journal.pone.0127453 June 19,10 /Hypokalemia and Outcomes in Peritoneal DialysisS3 Table. Risk factors for overall mortality. (DOCX) S4 Table. Risk factors for cardiovascular mortality. (DOCX) S5 Table. dar.12119 Risk factors for cardiovascular mortality in the matched cohort. (DOCX) S6 Table. Risk factors for infectious mortality. (DOCX) S7 Table. Independent risk factors for infectious mortality in the matched cohort. (DOCX) S8 Table. Time to first peritonitis episode–Overall population. (DOCX) S9 Table. Time to first peritonitis episode–Matched patients. (DOCX) S1 File. Ethic Review Boards that approved the study. (DOCX)AcknowledgmentsThe following centers participated in BRAZPD and contributed to the preparation of this article: Ameneg, Associa o Hosp. Bauru, Biocor Hosp. Doencas Cardiologicas, Casa de Saude e Mat N. Sra. Perp. Socorro, CDR Curitiba, CDR Goiania, CDR Imperatriz, CDR Sao Jose Pinhais, CDTR_Centro Dialise Transplante Renal, Centro Nefrologia Teresopolis, Centro Nefrologico Minas Gerais, Centro Trat. Doencas Renais Joinville, Centro Tratamento Renal Zona Sul, CLINEF Rio De Janeiro, CLINEPA Clinica de Nefrologia da Paraiba, CLINES, Clinese, Clinica do Rim do Carpina, Clinica Evangelico S/C Ltda, Clinica Nefrologia de Franca, Clinica de Nefrologia Santa Rita, Clinica de Nefrologica Sao Goncalo, Clinica Paulista de Nefrologia, Clinica Renal Manaus, Clinica Senhor Do Bonfim, Clinica Senhor Do Bonfim Ltda Filial, Clinica Tratamento Renal, Cuiaba Cenec, Clire Clinica de Doencas Renais, Famesp Botucatu, Unicamp_Univ. Est Campinas, Hosp. Clinicas FMRPUSP, Funda o Civil Casa Mis Franca, Funda o Inst Mineiro Est Pesq Nefrol, Gamen Rio de Janeiro, Gdf Hospital de Base, Histocom Sociedade Civil Ltda, Hosp Univ Prof Edgard Santos, Hosp Benef. Portuguesa Pernambuco, Hospital Cidade Passo Fundo, Hospital Clinica Univ Fed Goias, Hospital E Maternidade Angelina Caron, Hospital Evangelico Vila Velha Es, Hospital Geral Bonsucesso, Hospital Geral de Goiania, Hospital Infantil Joana de Gusmao, Hospital S Joao Deus, Hospital S Jorge, Hospital S Jose do Avai, Hosp Sao Vicente de Paula_J Pessoa, Hosp Sao Vicente de Paulo, Hospital Servidor do Estado Ipase, Hospital Univ Presidente Dutra Ma, Hospital Universitario Antonio Pedro, Hospital Vita Volta Redonda S/A, Iamspe Sao Paulo, Imip, Inst Capixaba Doencas Renais, Inst Capixaba Doencas Renais Cariacica, Inst Capixaba Doencas Renais Serra, Inst do Rim de Fortaleza, Inst do Rim de Marilia, Inst do Rim do Parana S/C Ltda, Inst do Rim Santo Antonio da Platina, Inst Hemodialise de Sorocaba, Inst Medicina Nuclear Endocrina, Inst Nefrologia de Mogi Das Cruzes, Inst Nefrologia de Suzano, Inst Nefrologia Souza e Costa, Inst Urologia e Nefrol Barra Mansa, Inst Urologia e Nefrol Sj Ri.
