Ase versus nucleoside reverse transcriptase inhibitor-based HAART through pregnancy. J Infect Dis 204:506514. 7 Epigenetics preterm Birth in Malawi 16. van den Akker T, Bemelmans M, Ford N, Jemu M, Diggle E, et al. HIV care have to have not hamper maternity care: a descriptive analysis of integration of solutions in rural Malawi. Brit J Obstet Gynaec 119:431438. 17. Kourtis AP, Fowler MG Antiretroviral use for the duration of pregnancy and risk of preterm delivery: Additional concerns than answers. J Infect Dis 204:493494. 18. Ndirangu J, Newell M L, Bland R M, Thorne C Maternal HIV infection linked to small-for-gestational age infants but not preterm births: evidence from rural South Africa. Hum Reprod 27:18461856. 19. McGready R, White NJ, Noster F Parasitological efficacy of antimalarials within the treatment and prevention of falciparum malaria in pregnancy 1998 to 2009: a systematic evaluation. Brit J Obstet Gynaec 118:123135. 20. Han Z, Mulla S, Beyene J, Liao G, McDonald SD Maternal underweight and also the 17493865 danger of preterm birth and low birth weight: a systematic evaluation and metaanalyses. Int J Epidemiol 23115181 40:65101. 21. Taylor-Robinson D, Agarwal U, Yoxall B, Diggle PJ, Platt MJ, et al. Quantifying the effect of deprivation on preterm births: A retrospective cohort study. PLoS 1 six: e23163. 22. Ota E, Tobe-Gai R, Mori R, Farrar D Antenatal dietary tips and supplementation to enhance power and protein intake. Cochrane database of systematic reviews 9: CD000032. 23. Huybregts L, Roberfroid D, Lanou H, Menten J, Meda N, et al. Prenatal food supplementation fortified with a number of micronutrients increases birth length: a randomized controlled trial in rural Burkina Faso. Am J Clin Nutr 90:15931600. 24. van den Broek NR, White SA, Ntonya C, Ngwale M, Cullinan TR, et al. Reproductive wellness in rural Malawi: a population-based survey. Brit J Obstet Gynaec 110:902-908. 25. van den Broek NR & Letsky EA Etiology of anemia in pregnancy in south Malawi. Am J Clin Nutr 72:pp. 247S256S. 8 ~~ ~~ Stathmin1 is an 18 kD cytosolic phosphoprotein, known to play an important role inside the cell cycle. Stathmin is expressed in all tissues. It is a critical regulator of microtubule dynamics through its microtubule destabilizing properties, Epigenetics including both prevention of polymerization and active promotion of microtubule depolymerization. Phosphorylation of stathmin on four serine residues in the beginning of the mitotic phase attenuates its destabilizing activities, allowing cells to form a mitotic spindle; dephosphorylation then takes place prior to exit of mitosis. Stathmin is also involved in intracellular transport, cell motility, polarity, maintenance of cell shape and regulation of apoptosis. A biomarker is defined as a ‘characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes or pharmacologic responses to a specified therapeutic intervention. Biomarkers can be divided in several types, such as prognostic; linked to the prognosis of a patient independent of remedy, and predictive biomarkers; that identify patient subpopulations most likely to respond to a therapy. Thus, reliable predictive biomarkers are of paramount importance for improved and individualized therapy. Stathmin is upregulated in lots of solid cancers, including endometrial cancer, and its upregulation has been associated with clinicopathological variables of aggressive disease such as increased threat of lymph node metastasis and poor survival, confirming stath.Ase versus nucleoside reverse transcriptase inhibitor-based HAART throughout pregnancy. J Infect Dis 204:506514. 7 Preterm Birth in Malawi 16. van den Akker T, Bemelmans M, Ford N, Jemu M, Diggle E, et al. HIV care need to have not hamper maternity care: a descriptive analysis of integration of services in rural Malawi. Brit J Obstet Gynaec 119:431438. 17. Kourtis AP, Fowler MG Antiretroviral use throughout pregnancy and threat of preterm delivery: Much more inquiries than answers. J Infect Dis 204:493494. 18. Ndirangu J, Newell M L, Bland R M, Thorne C Maternal HIV infection linked to small-for-gestational age infants but not preterm births: evidence from rural South Africa. Hum Reprod 27:18461856. 19. McGready R, White NJ, Noster F Parasitological efficacy of antimalarials in the therapy and prevention of falciparum malaria in pregnancy 1998 to 2009: a systematic assessment. Brit J Obstet Gynaec 118:123135. 20. Han Z, Mulla S, Beyene J, Liao G, McDonald SD Maternal underweight and also the 17493865 danger of preterm birth and low birth weight: a systematic overview and metaanalyses. Int J Epidemiol 23115181 40:65101. 21. Taylor-Robinson D, Agarwal U, Yoxall B, Diggle PJ, Platt MJ, et al. Quantifying the influence of deprivation on preterm births: A retrospective cohort study. PLoS 1 6: e23163. 22. Ota E, Tobe-Gai R, Mori R, Farrar D Antenatal dietary advice and supplementation to enhance power and protein intake. Cochrane database of systematic reviews 9: CD000032. 23. Huybregts L, Roberfroid D, Lanou H, Menten J, Meda N, et al. Prenatal meals supplementation fortified with multiple micronutrients increases birth length: a randomized controlled trial in rural Burkina Faso. Am J Clin Nutr 90:15931600. 24. van den Broek NR, White SA, Ntonya C, Ngwale M, Cullinan TR, et al. Reproductive wellness in rural Malawi: a population-based survey. Brit J Obstet Gynaec 110:902-908. 25. van den Broek NR & Letsky EA Etiology of anemia in pregnancy in south Malawi. Am J Clin Nutr 72:pp. 247S256S. 8 ~~ ~~ Stathmin1 is an 18 kD cytosolic phosphoprotein, known to play an important role in the cell cycle. Stathmin is expressed in all tissues. It is a critical regulator of microtubule dynamics via its microtubule destabilizing properties, including both prevention of polymerization and active promotion of microtubule depolymerization. Phosphorylation of stathmin on four serine residues within the beginning of the mitotic phase attenuates its destabilizing activities, allowing cells to form a mitotic spindle; dephosphorylation then takes place prior to exit of mitosis. Stathmin is also involved in intracellular transport, cell motility, polarity, maintenance of cell shape and regulation of apoptosis. A biomarker is defined as a ‘characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes or pharmacologic responses to a specified therapeutic intervention. Biomarkers can be divided in different types, such as prognostic; linked to the prognosis of a patient independent of therapy, and predictive biomarkers; that identify patient subpopulations most likely to respond to a treatment. Thus, reliable predictive biomarkers are of paramount importance for improved and individualized therapy. Stathmin is upregulated in a lot of solid cancers, including endometrial cancer, and its upregulation has been linked to clinicopathological variables of aggressive disease such as increased threat of lymph node metastasis and poor survival, confirming stath.
