Ronic moderate accelerated Recovery Comprehensive Incomplete No recovery Progression Relapsingremitting Secondary progressive Major progressive Progressiveremitting Aggressivemalignant P ..According to KruskalWallis testTable .Associations of YKL-06-061 COA Illness severity and age, illness duration, attack intervals, and number of presenting symptomsTotalMean SD Median (Variety)ChronicMean SD Median (Variety)MildmoderateMean SDAdvanced AcceleratedAggressive Malignant Median Median Median Mean SD Mean SD (Range) (Range) (Variety)P ….Age (years)..Illness duration ..(years) Age at disease ..onset (years) Quantity of ..symptoms Interval between .the st and nd .. attacks (Months). . . …………… …. …. …. . … .. .. …… .polysymptomatic illness onset, difficulty in walking, upper and lower extremity dysfunction, and progressive disease course.On the other hand, when several logistic regression was performed, the strongest determinant of disease severity was disease course (OR .for secondary progressive course andOR .for principal progressive relapse course).Difficulty in walking had a borderline association with illness severity OR .; P ).Although escalating quantity of symptoms at onset was found to become associated with far more serious illness, the relation was not statistically important (Table).Ir J neurol ; Baghizadeh et al.ijnl.tums.ac.ir JanuaryTable .Comparison of univariate and multivariate analysis Univariate ParameterOR CIMultivariateP OR CI PGender Female Male Age at illness onset (years) Disease duration Education (years) Constructive family history No Yes Illness course RR SP PP PR Quantity of symptoms Polysymptomatic onset No Yes Presenting symptoms Difficulty in walking Lower extremity dysfunction Upper extremity dysfunction Optic neuritis Bladderbowel dysfunction Sensory symptoms Oculomotor impairment Vertigo, hypoacousia.(Ref) … (Ref) …(Ref) .(Ref) …(Ref) ………………………………………………………(Ref) …(Ref) …………………………………………………….OR Odds ratio for acquiring worse conditions Determined by ordinal logistic regression Depending on many ordinal logistic regressionDiscussion Comparison with the benefits on the several research designed to establish prognostic elements in MS shows diverse findings and inconsistency about demographic and clinical prognostic determinants (Table).Doable explanations for such discrepancies observed in these research are as follows .Some PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21601637 of those studies are populationbased even though others are clinicbased (e.g.the existing study in Tehran).Clinicbased research may possibly contain sufferers with far more health-related interventions.However, quite a few chronic sufferers may possibly by no means seek health-related care.In referral centers (like those within the present study), alternatively, 1 may well locate far more patients with aggressive illness..Unique diagnostic criteria for patient inclusion (definite or attainable MS) also can be a reason for discrepancy..A few of the described studies are prospective whilst other individuals possess a retrospective design and style.Prospectivedata collection potentially brings elevated accuracy unless patient assessments are very infrequent or the desired outcome is reached in amongst these sparse examinations.In retrospective assignment, you can find fewer excluded patients and therefore significantly less certainty.Our study had the advantage of employing MSSS to rate disability.Consequently, it had the prospective of determining disease severity according to one assessment within a cross sectional s.
