Ne content material in the AD group was higher than that of the cascular dementia group (Figure ).Discussion PNU-100480 Description homocysteine is definitely an intermediate item of methionine metabolism.Numerous research showed that homocysteine was an independent risk element for coronary artery illness, cerebrovascular illness, peripheral vascular illness and other folks.Some studies held that hyperhomocysteinemia played a function within the occurrence and improvement of AD.Studies have shown that higher homocysteine brought on cognitive function and resulted in AD, which may well be associated with biochemical harm triggered by oxidative strain .Higher levels of homocysteine can markedly improve the content of oxygen free of charge radicals and promote the formation of nitric oxide.High levels of nitric oxide can turn out to be neurotoxic substances .Oxygen free radicals can promote schizolysis of APP ( amyloid protein precursor) and formation of A amyloid protein, as a result increasing the generation and deposition of A, which can be the primary pathological alter in AD.Our study result showed that when the AD group was compared using the typical control group, the MMSE score was decrease as well as the homocysteine content higher, using a statistically significant difference among the two groups (P ).When the AD group was compared together with the vascular dementia group, the MMSE scores were not considerably various involving the two groups (P ); the homocysteine content of your AD group was decrease than that in the vascular dementia group, with a statistically substantial difference (P ).According to the extensive outcome from the above documents, it was typically regarded as that the MMSE score and homocysteine content material could possibly be used as 1 of your PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21593114 indicators to distinguish AD and standard elderly subjects, along with the homocysteine content material as 1 on the indicators to distinguish AD and vascular dementia.The outcome of our metaanalysis was restricted inside the following aspects firstly, even though our study incorporated publications, we didn’t make stratified analysis on gender and distinctive ages, so we couldn’t see more detailed outcome; secondly, there existed choice bias that couldn’t be excluded along with the influence of confounding components that couldn’t be determined; additionally, there existed methodological defects in publications included in our metaanalysis, including not clearly explaining random approach, blinding method and other people, which affected our evaluation final results.It can be held in evidencebased medicine that the proof obtained from randomized controlled clinical trials has the strongest authenticity and reliability; and the complete conclusion is much more convincing from systematic evaluation on various RCT and metaanalysis, as compared with single RCT.Most research integrated in our analysis are retrospective casecontrol research and don’t belong for the RCT category inside the strict sense, which straight impacts the demonstration strength of our metaanalysis result.In the future, when generating systematic evaluation on multicenter RCT research among elderly persons, we are hopeful to get conclusive evidence around the relationship in cognitive function among homocysteine and AD, then supplying directions to clinical practice and producing clinical intervention tactic far more rational.Disclosure of conflict of interest None.Address correspondence to Dr.Yuan Zhong, Department of Geriatrics, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Yishan Road, Shanghai , China.Tel ; E mail [email protected]
ORIGINAL Investigation Article Victimisation and PT.
