T/12/1/Table three Erythrocyte membrane fatty acid composition in LZR and OZR rats fed CON, FLAX, FISH, or SDA diets for 12 weeksFatty acid ( of total) LA[18:2(n-6)]Lean CON 9.50 ?0.28 0.04 ?0.07a 0.04 ?0.02 0.03 ?0.05 25.63 ?0.51 0.05 ?0.11a 1.02 ?0.16 two.51 ?0.14 47.53 ?0.39 9.62 ?0.39 three.63 ?0.19 41.23 ?0.aObese FISH 9.72 ?0.28 0.10 ?0.07a 0.04 ?0.02 0.03 ?0.05 15.90 ?0.50 five.14 ?0.11f three.74 ?0.16 five.80 ?0.14 47.17 ?0.38 11.00 ?0.39 14.81 ?0.19 32.76 ?0.dMain effects FISH SDA six.73 ?0.31 0.61 ?0.08bc 0.20 ?0.02 0.40 ?0.05 18.13 ?0.56 three.98 ?0.12e four.64 ?0.18 3.28 ?0.15 47.31 ?0.43 12.36 ?0.43 12.88 ?0.21 30.67 ?0.eFLAX 9.61 ?0.28 0.43 ?0.07b 0.04 ?0.02 0.03 ?0.05 22.21 ?0.51 1.06 ?0.11b 3.67 ?0.16 3.74 ?0.14 47.58 ?0.39 9.94 ?0.39 8.92 ?0.19 37.23 ?0.cdSDA 8.26 ?0.29 0.64 ?0.07c 0.30 ?0.02 0.40 ?0.05 20.67 ?0.52 2.80 ?0.11d five.44 ?0.17 two.31 ?0.14 47.49 ?0.40 ten.14 ?0.40 11.63 ?0.20 33.01 ?0.eCON 7.76 ?0.30 0.14 ?0.07a 0.05 ?0.02 0.03 ?0.03 24.91 ?0.54 0.23 ?0.12a 1.19 ?0.17 two.91 ?0.15 47.35 ?0.41 11.91 ?0.42 4.48 ?0.20 38.61 ?0.aFLAX 7.97 ?0.29 0.70 ?0.07c 0.04 ?0.02 0.02 ?0.05 21.1 ?0.51 1.45 ?0.11c 3.08 ?0.17 4.33 ?0.14 47.23 ?0.39 12.12 ?0.40 9.59 ?0.19 35.33 ?0.bGenotype P 0.0001 P = 0.24 P = 0.78 P = 0.74 P = 0.056 P = 0.0017 P = 0.052 P = 0.0010 P = 0.93 P = 0.0006 P = 0.Eating plan P 0.iInteraction P = 0.eight.21 ?0.29 0.21 ?0.07a 0.04 ?0.02 0.03 ?0.05 14.80 ?0.52 five.41 ?0.12f three.17 ?0.18 six.50 ?0.14 47.67 ?0.40 12.12 ?0.40 15.31 ?0.20 31.33 ?0.bcALA[18:three(n-3)] GLA[18:three(n-3)]P 0.0001ii P 0.iiiP = 0.P = 0.52 P = 0.76 P = 0.SDA[18:four(n-3)] AA[20:4(n-6)]P 0.0001iii P 0.ivEPA[20:five(n-3)] DPA[22:5(n-3)]P 0.0001v P 0.0001 P = 0.99 P = 0.11 P 0.v viP 0.0001 P = 0.DHA[22:6(n-3)] SFA MUFA n3PUFA n6PUFAP 0.0001viiP = 0.ten P = 0.56 P = 0.23 P = 0.ten P = 0.P = 0.P 0.0001ivDifferent letters represent significance among signifies as determined by Bonferroni correction (P 0.05). Genotype Effect: Lean Obese; Obese Lean. Diet regime Effect: iCON, FLAX, FISH SDA; iiSDA, FLAX CON, FISH; iiiSDA CON, FLAX, FISH; ivCON FLAX SDA FISH; vFISH SDA FLAX CON; viSDA FLAX, FISH CON;viiFISH FLAX SDA, CON.Page six S1PR2 Antagonist site ofCasey et al. Lipids in Well being and Illness 2013, 12:147 lipidworld/content/12/1/Page 7 ofDHA, and AA content material was decrease with FLAX in comparison with SDA (P 0.0001).Subcutaneous ATFigure 2 Erythrocyte membrane Omega-3 Index in LZR and OZR rats fed CON, FLAX, FISH, or SDA diets for 12 weeks. Omega-3 Index ( EPA + DHA) was calculated from RBC membranes as described [22]. All graphed values represent LS interaction signifies ?SE. Letters represent important differences amongst indicates as determined by the Bonferroni correction (n = six, Genotype impact, P 0.0001 (Obese Lean); Eating plan effect, P 0.0001 (FISH SDA FLAX CON); DietGenotype interaction, P 0.0001).The percentage of ALA, SDA, MUFA, n3PUFA were reduced; whereas, the percentage of DPA, DHA, and SFA had been greater in subcutaneous AT of obese vs. lean rodents (Table 7; Genotype, P 0.0001). The percentage of DPA and MUFA was greater; when the percentage of ALA and n3PUFA have been reduce in subcutaneous AT with all n3PUFA-enriched diets (Diet program, P 0.0001). Similar to P/Q-type calcium channel Antagonist list epidydimal AT, the percentage of EPA, DPA, DHA, and SFA have been higher with FISH vs. FLAX or SDA (Diet regime, P 0.0001). On the other hand, the percentage of SDA, AA, and n3PUFA have been higher with SDA vs. FISH or FLAX (Diet regime, P 0.0001). When compared with FLAX, the percentage of EPA, DPA, and DHA were reduced with SDA (Diet regime, P 0.0001).Soleus muscleFISH vs. FLAX or SDA (Eating plan, P 0.05). Alterna.
